Synthetic Studies on Aromatic Heterocyclic Compounds

Palladium-catalyzed benzylation of heterocyclic aromatic compounds.

Broadly applicable palladium-catalyzed heteroarene benzylation reactions are described with a focus on the most challenging heterocyclic classes under traditional benzylation techniques such as sulfur-containing heterocycles and those bearing functional groups that would be incompatible with reactions requiring Lewis acids and/or strong bases.

Synthetic studies on heterocyclic natural products.

This article reviews past and ongoing research in the author's laboratory directed toward the synthesis of natural products displaying an azaspirocyclic framework, or incorporating a medium-ring nitrogen heterocycle. New synthetic technologies were devised in order to address the synthetic problems posed by the target molecules. Thus, efforts in the area of azaspirocyclic substances have relied...

Sorption of binary mixtures of aromatic nitrogen heterocyclic compounds on subsurface materials.

Perspectives on polyhalogenated aromatic compounds.

Mechanisms of bone invasion by squamous carcinomas of the head and neck have, been investigated using fresh tumours and established tumour cell lines in an in vitro bone resorption assay with 45Ca-labelled mouse calvaria. Fresh tumours regularly resorb bone in vitro. Activity is consistently reduced by indomethacin. The tumours release E2 prostaglandins (PGE2) in amounts sufficient to account f...

Microbial metabolism of homocyclic and heterocyclic aromatic compounds under anaerobic conditions.

INTRODUCTION....................................................................... 43 ANAEROBIC MICROBIAL PROCESSES ....................................................................... 43 Microbial Diversity......... 0 43 Representative Degradative Pathways of Aromatic Compounds under Anaerobic Conditions ...............44 METABOLISM OF HOMOCYCLIC AROMATIC COMPOUNDS UNDER ANAEROBIC CONDITIO...